Sorkin is known for portraying Calliope Jones on the NBC daytime serial Days of Our Lives and for serving as the real-life inspiration and voice for DC Comics character Harley Quinn, co-created by her friend Paul Dini on Batman: The Animated Series.

[3] Sorkin began her career in cabaret in the late 1970s and early 1980s as a member of the comedy group The High-Heeled Women, alongside Mary Fulham, Tracey Berg, and Cassandra Danz.

She additionally claimed that after she denounced the move as being racially motivated, Di Bona changed plans and hired new cohost Tawny Kitaen, who was also white.

[6] Sorkin's writing included for the Tiny Toon Adventures 1990–1992 television series, and co-writer of the story and screenplay of the 1997 Jennifer Aniston film, Picture Perfect.

[citation needed] Alongside providing the voice, the character of Harley Quinn was based on her,[7][8] after Paul Dini (her friend since college), saw her play a jester from a dream sequence in the soap opera Days of Our Lives.

[21] A dedication plaque to her and castmate Kevin Conroy were featured as easter egg in the 2024 video game, Suicide Squad: Kill the Justice League.