The Armenian Prelacy of Isfahan, (Armenian: Սպահանի հայոց թեմ ; Persian: خلیفه‌گری ارامنه اصفهان), is Oriental Orthodox Christian diocese (or eparchy) of the Armenian Apostolic Church in New Julfa, Isfahan, Iran.

It is within the ecclesiastical jurisdiction of the Catholicossate of the Great House of Cilicia, seated in Antelias, since 1960.

It was originally founded by Khachatur Kesaratsi after establishment of New Julfa in early 17th century.

The Diocese of Isfahan and Southern Iran is currently headed by Archbishop Sipan Kashchian.

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