He played in Major League Baseball (MLB) for the Pittsburgh Pirates, Miami Marlins, and Seattle Mariners.

Prior to playing professionally, Caminero attended Colegio Buen Pastor in the Dominican Republic.

His 2013 stats in the minor were a 3.48 ERA, a 1.01 WHIP, 69 strikeouts, and 6–2 record with 5 saves playing for both the Jacksonville Suns and the New Orleans Zephyrs.

He made his Major League debut on the same day, throwing a scoreless inning while striking out one and hitting a batter.

He started the 2014 season with the Marlins Triple A team, the New Orleans Zephyrs, but was called up when Jacob Turner was put on the DL with a shoulder injury.

[4] On December 17, Caminero signed with the Yomiuri Giants of Nippon Professional Baseball for a 1-year deal worth $1.15 million.

On January 3, 2019, Caminero signed a minor league deal with the New York Mets that included an invitation to spring training.

On February 12, 2022, Caminero announced his retirement from professional baseball, and that he would be joining the Houston Astros organization as a minor league pitching instructor.