The arrondissement of Cayenne is an arrondissement of France in the French Guiana department in French Guiana region.

[3] It is the smallest of the three arrondissements in French Guiana, but also its most populated.

The communes of the arrondissement of Cayenne, and their INSEE codes, are:[2] The arrondissement of Cayenne, containing the coastal strip of French Guiana, was established in 1947.

[5] Before 2015, the arrondissements of French Guiana were subdivided into cantons.

The cantons of the arrondissement of Cayenne were, as of January 2015:[6] A government decree of October 26, 2022 detached the four communes of Saint-Georges, Camopi, Ouanary, and Régina from the arrondissement of Cayenne to form the new arrondissement of Saint-Georges.