[1][2] On July 25, 2020, Hurricane Hanna’s storm surge flooded the museum's barge dock, however, no artwork was damaged.

Most of the Museum's collection lie in the areas of paintings, photographs, sculptures, ceramics, glass, crafts, works of art on paper, and large installation pieces.

[4] The main building, which opened in 1972, was designed by renowned architect Philip Johnson, who is regarded as one of the founders of postmodern architecture.

The Art Museum of South Texas is often identified as one of Johnson’s finest small public buildings and is an early example of postmodern architecture in the United States.

[6] In 1997, the museum board contacted the famed Mexican architect Ricardo Legorreta, who had recently designed the new building for the main branch of the San Antonio Public Library.