The school is part of the Mathematics, Engineering, Science Achievement program and is under the direct guidance of California State University, Long Beach.

Artesia High School is a member of the 605 League of the CIF Southern Section and is renowned for its competitive sports teams.

[5] The boys' basketball team, which featured future NBA All-Star James Harden, was ranked first in California during the 2005–2006 season.

The school won the CIF Division III championship with a record of 33 wins and a single loss.

[6] On March 24, 2007, the boys' basketball team defeated Bishop O'Dowd High School from Oakland for the CIF Division III State Championship title, and celebrated Artesia's second back-to-back D-III title and fifth overall state championship.