Elections were held on November 2, 2010, to determine Missouri's nine members of the United States House of Representatives.

[9] Results of the 2010 United States House of Representatives elections in Missouri by district:[10] Lacy Clay Democratic Lacy Clay Democratic The 1st district included Ferguson, Florissant, Hazelwood, Spanish Lake, and parts of St. Louis and University City.

[11] In 2010 Clay's opponent in the general election was Republican nominee Robyn Hamlin, an insurance agent.

[22] In 2010 Akin's opponent in the general election was Democratic nominee Arthur Lieber, the co-founder of the Crossroads College Preparatory School.

[25] Bill Haas and Jeffrey Lowe also sought the Republican nomination.

[26] Liz Lauber, a government and industry relations communications consultant for Wells Fargo, ended her campaign for the Republican nomination in April 2010.

[19] In 2011 Lieber wrote and published a book about his campaign entitled An Unlikely Candidate: Reflections on My Run for Office.

[35] In 2010 Carnahan's opponent in the general election was Republican nominee Ed Martin, a former chief of staff to Governor of Missouri Matt Blunt.

[38] David Arnold and Edward Crim also sought the Democratic nomination.

John Wayne Tucker[39] and Rusty Wallace, a computer-aided design technician,[40] also sought the Republican nomination.

[3] In November 2010 The Rothenberg Political Report rated the race as "Democrat Favored".

[48] The same year Martin unsuccessfully ran for Missouri Attorney General.

[53] Leonard Steinman, a salvage dealer and perennial candidate, also sought the Democratic nomination.

[54] Brian Clark; Arthur Madden; Eric McElroy; Jeff Parnell; Brian Riley; James Scholz;[51] Bill Stouffer, a member of the Missouri Senate; and Roy Viessman, a former member of the Jefferson City Council,[55] also sought the Republican nomination.

[61] In a poll of 300 likely voters, conducted in October 2010 by Wilson Research Strategies, Hartzler and Skelton were tied with 42 percent apiece.

[3] In November 2010 The Rothenberg Political Report rated the race as a "pure toss-up".

[67] Emanuel Cleaver Democratic Emanuel Cleaver Democratic The 5th district included Belton, Grandview, Raytown, and parts of Independence, Kansas City and Lee's Summit.

[68] In 2010 Cleaver's opponent in the general election was Republican nominee Jacob Turk, who also ran in 2006 and 2008.

Jerry Fowler; Patrick Haake;[69] Ron Shawd, a former car dealer;[71] and Ralph Sheffield also sought the Republican nomination.

In 2010 Graves's opponent in the general election was Democratic nominee Clint Hylton,[79] an insurance salesman.

[89] Libertarian Party nominee Kevin Craig and write-in candidate Nicholas Ladendorf also ran.

[90] Jack Goodman, a member of the Missouri Senate; Steve Hunter, a former member of the Missouri House of Representatives; Mike Moon, a farmer; Darrell Moore, the Greene County prosecuting attorney; Gary Nodler, a member of the Missouri Senate; Michael Wardell, a small business owner; and Jeff Wisdom, an Iraq War veteran, also sought the Republican nomination.

[91] Sarah Steelman, the former State Treasurer of Missouri, announced in September 2009 that she would not run in the 7th district in 2010.

[101] On October 29, 2010, an email was sent to local media, purportedly by Eckersley, which falsely claimed that he had ended his campaign.

Eckersley later filed a complaint with the Federal Election Commission (FEC) alleging that Long may have been involved in the hoax.

As the FEC found no evidence that Long's campaign or the Republican Party was involved, under the law electoral fraud had not occurred.

[105] In 2010 Emerson's opponent in the general election was Democratic nominee Tommy Sowers, a former member of the United States Army Special Forces.

[106] Independent candidate Larry Bill, a real estate investor and building contractor;[107] and Libertarian Party nominee Rick Vandeven, a technician with Procter & Gamble,[108] also ran.

[118] In 2010 Luetkemeyer's opponent in the general election was Libertarian Party nominee Christopher Dwyer.

[122] Prior to the election FiveThirtyEight's forecast gave Luetkemeyer a 100 percent chance of winning.