Artistic swimming competitions at the 2021 Junior Pan American Games in Cali, Colombia were held from 2 to 4 December 2021 at the Piscinas Hernando Botero O'byrne.

*   Host nation (Colombia)A total of 80 artistic swimmers will qualify to compete at the games.

As host nation, Colombia qualifies the maximum team size of nine athletes (eight women + 1 man).

[1] Canada and the United States, as being the only members located in zone 4 and zone 3 respectively, automatically qualify a full team.

The South American region and the Central American and Caribbean region will qualify three teams and five duets each.