The handball competition of the 2021 Junior Pan American Games in Cali, Colombia was held from 23 November to 4 December at the Iván Vassilev Todorov Arena, the events were played by U23 national teams and awarded one place in both genders to the handball tournament of the 2023 Pan American Games.

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All times are local (UTC−5).

All times are local (UTC−5).

FT: 28–28 Pen: 4–3