The swimming competitions at the 2021 Junior Pan American Games in Cali took place 26 to 30 November 2021.

[1][2] Similar to the program's format in 2015, swimming features a total of 36 events (17 each for men and women and 2 mixed).

Each National Olympic Committee (NOC) may use proven swim times attained during the qualification period of those swimmers who have met the qualifying standards established by the UANA for the 2021 Junior Pan American Games at a competition recognized by the FINA.

[1] Each National Olympic Committee (NOC) may use proven swim times attained during the qualification period of those swimmers who have met the qualifying standards established by the UANA for the 2021 Junior Pan American Games at a competition recognized by the FINA.

The time standards (all long course) for the 2019 Pan American Games are: A total of 37 countries qualified swimmers or received universality spots.