As-Safira (Arabic: السَّفِيْرَة / ALA-LC: as-Safīrah; Aleppo dialect: Sfīre) is a Syrian city administratively belonging to the Aleppo Governorate.

As Safīrah has an altitude of 348 meters (1,142 ft), and a population of 106,382 as of 2007[update], making it the 11th largest city per geographical entity in Syria.

Medieval geographer Yaqut al-Hamawi spells the name Asfīrah[3] (أسفيرة), not as-Safira (السفيرة), which indicates that the definite article in the modern spelling is a result of hypercorrection.

Since ancient times the city has been the distribution point for salt gathered from the nearby Sabkhat al-Jabbul.

The Sfire I Treaty which may contain 8th century BCE evidence of a deity called "Most High."