In the 1570, he defended against an invasion by Oda Nobunaga into Echizen at Siege of Kanegasaki.
[1]: 62–63 Following the battle of Anegawa, Kagetake's launch a counter attack at the battle of Shimosakamoto, his troops killed over 750 soldiers in the Oda army including Mori Yoshinari and Oda Nobuharu (Nobunaga’s younger brother).
In 1573, he led an Asakura army of 20,000 soldiers confronted 30,000 Oda troops under the direct command of Nobunaga, but defeated at the Battle of Tonezaka.
After Asakura Yoshikage died in the Siege of Ichijodani Castle, Kagetake surrendered to Nobunaga.
In 1574, he responded to uprisings of the Echizen Ikkō-Ikki by surrendering, despite the ongoing struggle between the Ikkō sect and the Oda.