Ascoli Piceno railway station is situated at Piazza della Stazione, to the east of the town centre.

[1] The original operator of the station was the Società per le Strade Ferrate Meridionali (SFM) (English: Company for the Southern Railways), which operated the whole of the Ascoli Piceno branch as part of the Rete Adriatica (English: Adriatic Network).

The station yard is also equipped with a group of sidings dedicated to the storage of vehicles not in service.

Their main origins and destinations are San Benedetto del Tronto, Civitanova Marche and Ancona.

In the square in front of the passenger building is a bus terminal for urban and suburban buses.