Since her debut in Prema Kosam (1999), she has acted in over 50 films and co-starred with noted actors like Venkatesh, Balakrishna, Sudeep, Shivarajkumar, Vijayakanth, Prabhu, Karthik, Jagapati Babu and Rajasekhar.

[4] The producer of the film rechristened her as Asha Saini; some years later she would adopt a new screen name, Mayuri, as per the advice of an astrologer, before eventually reverting to her original name.

[8] Her second Hindi film, Love in Nepal (2004), also produced by Agarwal, saw her paired with popular playback singer Sonu Nigam.

[9] In March 2008, she was arrested in Chennai for supposedly having forged visa documents,[7] and was subsequently banned from the Tamil film industry.

In 2015, Flora Saini played the role of Muskan in MSG: The Messenger starring Gurmeet Ram Rahim.