[1] In December 2013, Deshmukh had undertaken an indefinite fast to press for formation of a separate Vidarbha state.

He strongly contested assembly elections in 2019 against the then chief minister (Devendra Fadnavis).

He has been expelled by the grand old party for his statements against party leader Rahul Gandhi and Maharashtra Pradesh Congress Committee (MPCC) President Nana Patole for a period of six years.

In October 2024, he got ticket offered from BJP for Maharashtra Vidhan Sabha Election 2024 from Savner Kamleshwar Vidhan Sabha Seat against ex-Minister Sunil Kedar's Wife Anuja (Vijaykar) Kedar.

On Result Day (i.e. 23 November 2024), Dr. Ashish Deshmukh won the Savner Kalmeshwar Vidhan Sabha Seat by a massive margin of 26,401 votes.