Ashot Melikjanyan or Melikdzhanyan (20 April 1952 — 12 November 2001) was a Soviet Armenian actor.

Melikdjanyan began his acting career at the Yerevan Dramatic Theater.

His first on-screen performance was playing the role of Meruzhan in the 1972 film Ayrik.

After the Soviet Union collapsed, Melikdjanyan emigrated with his family to the United States, where he worked at a jewelry factory which supervised one of its branches in the Dominican Republic.

Melikdjanyan was killed in the crash of American Airlines Flight 587 in New York City on 12 November 2001.