[2] Played from a first-person perspective, the game stars Ezio Auditore da Firenze, Connor, and Kassandra as its protagonists.

An unnamed hacker is hired by the Assassins Rebecca Crane and Shaun Hastings to infiltrate an Abstergo project called "Nexus Eye".

The project, led by Dominika Wilk, has the goal of retrieving the code of fragments of an Isu machine and combining it with the Animus to create a computer capable of predicting and influencing human behavior.

Following her trail, Ezio seeks help from his friend Antonio de Magianis, who points him to Francesco Rizzo, a merchant involved with the attack.

Their leader, Critias, tasks Kassandra to eliminate a group of thieves, before asking her to assassinate his fellow statesman Theramenes for his own political gain.

In 1777, Connor relocates to Newport, Rhode Island, where William Barton asks him to find a spymaster named Jeremiah Scudder, who has British general Richard Prescott's schedule that they can use to kidnap him.

[4] In September 2020, at the digital event of Facebook Connect, Red Storm Entertainment's VP of Product Development, Elizabeth Loverso, revealed several AAA game franchises coming to virtual reality format to the public.

"[8] Matt Kamen from Wired wrote that the game was "full of passion and dedication, not only to creating an experience that can be delivered in virtual reality, but one that feels authentic, essential even, for Assassin's Creed fans"[4] According to Ubisoft's CEO, Yves Guillemot, Nexus VR had disappointing sales, which resulted in Ubisoft not increasing its investment in VR.