Assiscunk Creek is a tributary of the Delaware River in southwestern New Jersey in the United States.
The name of the creek was also applied to the Axion people, a band of Lenape Indians who lived in the region until the late 17th century.
Assiscunk Branch and Barkers Brook enter between U.S. Route 206 and the New Jersey Turnpike crossing.
The creek begins to widen on the outskirts of Burlington City, where it empties into the Delaware River.
Assiscunk Creek is an impaired river but has improved greatly in recent years thanks to hard efforts to stop the pollution.