The history of Assumption High School began in 1951 when the Most Reverend John A. Floersh, Archbishop of Louisville, asked the Sisters of Mercy to establish a new high school at the corner of Bardstown Road and Tyler Lane.

[3] The first principal was Sr. Mary Prisca Pfeffer, and the faculty consisted of five Sisters of Mercy.

For three years, the sisters lived on the third floor of the school until there were finally enough funds to build a separate convent.

[citation needed] Assumption is accredited by the Southern Association of Colleges and Schools and the Kentucky Department of Education.

[citation needed] Assumption offers 15 sports sanctioned by the Kentucky High School Athletic Association (KHSAA) which include archery, basketball, bowling, cheerleading, cross country, dance, field hockey, golf, lacrosse, soccer, softball, swimming, tennis, track and field, and volleyball.

[5] The Field Hockey team has won the KHSAA State Championship 10 times, with the most recent being in 2019.