Astrophytum caput-medusae (synonym Digitostigma caput-medusae) [1] is a species of cactus native to Mexico, specifically the state of Nuevo León; the plant is reported to grow wild only at a single location.

[1] This species differs from the conventional star-shaped phenotype associated with other Astrophytum members.

[2] The plant is characterized by a cylindrical, reduced stem with triangular or cylindrical tubercles producing yellow flowers with orange perianth sections.

[3] Propagation by seed, tissue culture or via grafting have all been reported.

[2] The species is considered critically endangered by the IUCN due to the plant's limited growth range, destruction by livestock and over collection of wild specimen by plant collectors [1]