Astrothelium trypethelioides is a species of corticolous (bark-dwelling) lichen in the family Trypetheliaceae.

The type specimen was collected by Harrie Sipman along the Carapo River (Cerro Guaiquinima [es], Bolivar) at an altitude of 800 m (2,600 ft).

The lichen has a smooth, somewhat shiny, pale yellowish-grey thallus that covers areas of up to 9 cm (3.5 in).

Its ascospores are hyaline, spindle-shaped (fusiform) with between 7 and 9 septa and dimensions of 49–52 by 13–16 μm.

No lichen products were detected in the species using thin-layer chromatography.