Astrothelium variabile is a species of corticolous (bark-dwelling) lichen in the family Trypetheliaceae.

Found in Bolivia, it was formally described as a new species in 2016 by lichenologists Adam Flakus and André Aptroot.

The type specimen was collected near the biological station in the Beni Biological Station Biosphere Reserve (Yacuma Province, Beni Department) at an altitude of 175 m (574 ft); there, in a lowland Amazon forest, it was found growing on bark in Beni savanna.

The species epithet variabile alludes to the variable amounts of lichexanthone in different regions of the thallus.

Astrothelium ochroleucoides is somewhat similar in external appearance, but it has smaller ascospores than A. variabile.