He attained a great fortune through his commerce and became one of the richest men in the nascent nation of Bolivia.

His descendants include the famed Princess of La Glorieta, a very popular figure in Bolivia, Atanasio de Urioste Velasco, and the industrialist Armando Julio Urioste Arana.

During his childhood, the province of Vizcaya had been devastated by the Napoleonic Wars and, as such, his father would send him to Buenos Aires at the age of 14 to live under the tutelage of his maternal uncle, Don Manuel de las Carreras.

Transporting silver and other resources from Upper Peru to the global market, Urioste became very wealthy and, as such, came to be a powerful figure in the new Bolivian Republic.

[3][4][5] Married to Micaela Gómez, Urioste would have six children: Melitón; Lorenza Pastora; Juan Manuel; Ezequiel; María Encarnación; and Rosa Petronila.