The Aterno-Pescara (ancient Aternus from the Greek Aternos, Άτερνος) is a river system in Abruzzo, eastern central Italy.

Having the greatest discharge basin of the rivers flowing into the Adriatic Sea south of the Reno, the Aterno has its origin in the Monti della Laga, near Montereale and Lago di Campotosto in the province of L'Aquila.

The river flows in a southeastern direction past Pizzoli, L'Aquila, Paganica, San Demetrio ne' Vestini, and Castelvecchio Subequo through the Appennino Abruzzese mountains.

[1] It subsequently flows until the Valle Peligna (or Sulmona plateau) near Raiano, where it curves northward and receives its main tributary, the Sagittario.

The river flows in a northeast direction past Tocco da Casauria and Torre de' Passeri before forming the border between the province of Pescara and the province of Chieti for a short distance.