His son, Manivannan (Akkineni Nageswara Rao), is a kind-hearted individual who always assists the less fortunate, despite his privileged background and lack of interest in the family business.

Muthuraja's sister, Maragatham (M. S. Draupathi), takes charge of the business affairs, while her son Raju (Manohar), a wastrel residing in Madras, is entrusted with educating Manivannan.

One day, Manivannan attends a dance drama at a college hostel and meets a young dancer named Nirmala (Vyjayanthimala), with whom he falls deeply in love.

In a fit of rage, Raju murders the man, leading to a series of complications when Manivannan is falsely accused of the crime.

Athisaya Penn is a remake of the 1957 Hindi-language film Aasha,[2] and has both the lead actress Vyjayanthimala and director M. V. Raman returning.