Atlantihyla melissa is a species of frog in the family Hylidae, endemic to Honduras.

It has been observed between 780 and 1680 meters above sea level in the Cordillera Nombre de Dios mountains.

This frog exhibits considerable sexual dimorphism but scientists note large amounts of inter-individual variation as well.

[3] These frogs live in riparian habitats with fast-moving water and rocky beds with pools nearby.

[3] Scientists named this frog after fellow researcher Isis Melissa Medina-Flores, a biologist who studied the amphibians of Honduras.