Atmore was first recorded as a stop called Williams Station[8] on the Mobile and Great Northern Railroad.

[2] Climate is characterized by mild to high temperatures and evenly distributed precipitation throughout the year.

[20] For most of the 20th century, the Atmore area was primarily a farming, timber, and light industry community.

Major commercial industries have been Masland Carpets, Alto, and a local lumber company.

For many years, the Vanity Fair lingerie company operated a manufacturing sewing plant in Atmore, offering employment to local citizens and surrounding communities.

[21][22] Holman Correctional Facility is located north of the city,[23][24] and features a male death row and execution chamber.

An adjunct campus of Coastal Alabama Community College Brewton is located here, offering associate degrees and technical school training.

[31] The town is serviced by two freight railroads, the Alabama and Gulf Coast Railway and CSX.

Historically, Atmore had a Frisco Railway station, served by a section of the railroad's Sunnyland passenger train.

Atmore station was later served by Amtrak's Gulf Breeze train (Birmingham-Montgomery-Mobile) until that service ended in 1995.

[35] Atmore Community Hospital, an affiliate of Infirmary Health Systems of Mobile, offers full acute care in a two-story facility.