[4] In the decisive Battle of Gaugamela (October 331 BCE) between Darius and Alexander, Atropates commanded the Achaemenid troops of Media and Sacasene.
[5] Later that year, Alexander visited Atropates in Ecbatana with his good friend and second-in-command Hephaestion, who fell ill and died in October 324 BCE.
At this time, "[i]t was related by some authors, that Atropates on one occasion presented Alexander with a hundred women, said to be Amazons; but Arrian ([Anabasis] vii.
At some point thereafter, Atropates refused to convey allegiance to the diadochi and made his part of Media an independent kingdom, while his son-in-law Perdiccas was eventually murdered by Peithon in the summer of 320 BCE.
[9][8] Medieval Arab geographers came up with other explanations of the name, such as 'fire temple' or 'guardian of the fire', from the Persian words āzar 'fire', and pāyegān 'guardian/protector'.