In 2008, he won the Silver Slugger Award for the designated hitter position after batting .304 with 32 home runs and a career-high 108 RBI.

[3] In 1983, when he was six years old, his father, Aubrey II, was shot and killed as an innocent bystander in a domestic dispute while working as an electrician.

[9] Huff was the Tampa Bay Devil Rays' fifth-round selection (162nd overall) in the 1998 Major League Baseball (MLB) draft.

[10] He spent 1998 with the Charleston RiverDogs of the single-A South Atlantic League, where he batted .321 with 85 hits, 19 doubles, 13 home runs, and 54 RBI in 69 games.

In 108 games, he batted .316 (fifth) with 129 hits, 36 doubles (fourth, behind Clark's 41, Ryan Jackson's 38, and José Fernández's 37), 20 home runs, and 76 RBI.

[8] Huff was called up by the Devil Rays at the beginning of August to be the starting third baseman after Vinny Castilla suffered an injury.

[20][22] After batting .243 with six home runs and 33 RBI in his first 92 games, he was optioned to Durham on August 23 when Cox came off the disabled list (DL).

[20][24] On September 19, he had three hits and five RBI, including a game-winning single against David Cone, in a 12–2 victory over the Boston Red Sox.

[8] Huff missed the first month of 2002 with a broken cheekbone and began the season in the minor leagues before getting called up on May 28 to replace the struggling Jason Tyner on the roster.

[28] In 113 games, Huff finished tenth in the American League (AL) with a .313 batting average and had 142 hits, 25 doubles, 23 home runs, and 59 RBI.

[37] Huff's single-season totals in hits, doubles, home runs, and RBI had been matched by 11 players in major league history as of 2012.

[45] On April 18, Huff had four RBI and hit the 100th home run of his career, a three-run shot against Jaret Wright in a 19–8 loss to the Yankees.

[45] On July 22, he hit the first grand slam of his career, a game-winning home run against Bruce Chen in a 7–5 victory over the Orioles.

[49] He was placed on the disabled list for the first time in his career on April 12 with a sprained left knee suffered in a collision with Nick Green the day before.

[53] On July 12, 2006, the Houston Astros acquired Huff from Tampa Bay for minor leaguers Mitch Talbot and Ben Zobrist.

[54] Huff was used at third base for the Astros until August 1, when he was moved to right field following regular third baseman Morgan Ensberg's return from the DL.

[49][55][56] In his debut with the Astros on July 13, the first game after the All-Star break, Huff had two hits, including a three-run home run against Randy Messenger in a 5–1 victory over the Marlins.

[8] On August 17, 2009, Huff cleared waivers and was traded to the Detroit Tigers in exchange for pitching prospect Brett Jacobson.

In Game 4 of the NL Division Series (NLDS) against the Atlanta Braves, he had a ninth-inning, two-out, game-tying RBI single against Mike Dunn in a 3–2 Giants' victory.

[92] In Game 4 of the World Series against the Texas Rangers on October 31, he hit a game-winning two-run home run against Tommy Hunter in a 4–0 Giants' victory.

[92] Huff filed for free agency after the 2010 season, but on November 23, 2010, he re-signed with the Giants on a two-year, $22 million contract with a club option for 2013.

[96][97] He drew a pinch-hit, game-winning, bases loaded walk on April 30 against John Lannan in a 2–1 victory over the Washington Nationals.

[102] On April 21, because the Giants did not have any infielders available, Huff was positioned at second base for the first time in his career in the ninth inning of a tied game against the Mets.

[102][105] On June 15, he was placed on the DL with a sprained right knee that he suffered jumping over a dugout railing to celebrate Matt Cain's perfect game.

[117] In February 2017, he released a book, co-written by Stephen Cassar, entitled Baseball Junkie, in which he opens up about his "battle with anxiety and the pressure of playing in the Major Leagues".

[125][4] During the Giants' 2010 playoff race and postseason, Huff became known for wearing a red "rally thong", which he joked would help the team win.

[4][128] Huff has supported the policies of current President Donald Trump,[129] and has made controversial statements considered sexist, transphobic, and violent in nature.

[131] In early January 2020, Huff was criticized after tweeting in response to a comment on the site which talked about invading Iran and kidnapping women from the country.

"[136] His behavior eventually prompted the Giants to ban Huff from a 2020 ceremony honoring their 2010 World Series championship.

[137] The team wrote that its reason was: "Aubrey has made multiple comments on social media that are unacceptable and run counter to the values of our organization.