Scutaro made his major league debut with the New York Mets in 2002, and subsequently played for the Oakland Athletics, Toronto Blue Jays, Boston Red Sox, Colorado Rockies and San Francisco Giants.

[8] Scutaro's first promotion to the majors came on July 19 when the Mets recalled him from the Tides to replace the injured Joe McEwing.

[10] Scutaro introduced himself to Mets manager Bobby Valentine that afternoon while the latter was eating lunch at the hotel in Cincinnati where the team was staying.

[11] Scutaro landed a starting second baseman position after Mark Ellis had a season-ending shoulder injury during 2004 spring training.

[13] On November 18, 2007, Scutaro was traded to the Toronto Blue Jays for minor league pitchers Kristian Bell and Graham Godfrey.

[16] On April 12, 2010, Scutaro recorded the first hit in Target Field history on a single up the middle in the first inning off Minnesota Twins starter Carl Pavano.

[20] On July 27, 2012, Scutaro was traded, along with cash considerations, to the San Francisco Giants for infielder Charlie Culberson.

[21] In a game against the St. Louis Cardinals at Busch Stadium on August 8, 2012, Scutaro drove in a career high seven runs, including a grand slam.

[13][23] On October 28, in the tenth inning of Game 4 of the 2012 World Series, Scutaro drove in Ryan Theriot for the winning run, as the Giants swept the Detroit Tigers.

[26] He underwent surgery on September 27 that inserted a pin in his left pinkie correcting his mallet finger, an injury he suffered on June 11 against the Pirates when he was hit by Tony Watson.

He played in five games in July before his back issues forced him to return to the disabled list for the remainder of the season.

Venezuela won the bronze medal in 2009, but in 2013 earned an early exit after a loss to Puerto Rico 6–3.