It can lead to failure of treatment in people due to a decrease in drug concentrations, increase in clearance, or shorter half life.
Normal kidney function measured by creatinine clearance varies in different populations based on age, gender, race, fluid balance, and other factors, but also can be affected by diseases themselves.
For this reason, kidney function (and thus medication elimination) has been approximated by measuring creatinine clearance, or calculating an estimated glomerular filtration rate (eGFR), since 1976.
[3][4] This led to the realization that some burn patients required higher than expected doses of aminoglycosides to obtain the same serum concentration of drug.
Scoring methods may use factors such as the following to predict ARC in critically ill patients: Augmented renal clearance may result in failure of treatment due to the increased elimination of drugs.
ARC influences the recommended dosages for antibiotics including aminoglycosides, beta-lactams, fluoroquinolones, and vancomycin in critical care.
In any case, the occurrence of ARC is managed through pharmacokinetic monitoring and adjusting medication dosages, frequencies, or timing to ensure adequate response.