He was born in the town of Buzancy, Ardennes, and died in Paris.
Later he was a professor of therapeutics (1902) and clinical medicine (1905) at Hôtel-Dieu.
He published many articles and books on a wide array of medical subjects.
With neurologist Maurice Villaret (1877–1946), he conducted extensive research of portal hypertension.
[1] Gilbert described a hereditary cause of increased bilirubin[citation needed]; today this disorder is known as Gilbert's syndrome and is believed to be caused by a deficiency of the enzyme glucuronosyltransferase.