[2] A high school athlete, multiple surgeries from Marfan syndrome during his teenage years turned him towards music.

In December 2016, Carlile departed from Of Mice & Men due to his Marfan syndrome and the effects that his vocal performances were having on his body.

[9] Their self-titled debut album was officially announced to be released on February 23, 2010, but was delayed until March 9 for finishes on production.

[15][16][17] In September 2010, shortly after the departure of Craig Owens of Chiodos, rumors that Carlile would replace him circulated quickly, but were denied when Brandon Bolmer was announced as vocalist.

[20] In the early morning of March 30, 2013, Carlile was arrested in Bowling Green, Ohio with drum technician Lionel Robinson II, he was later charged with felonious assault.

[24] In October 2016, the band pulled out in the midst of a European tour so that Carlile could seek medical treatment after experiencing pain during a show in Portsmouth.

[25] In late November, Carlile elaborated in a series of tweets that, as someone with Marfan syndrome, he wouldn't "get better" and that he had undergone multiple surgeries "just so I can function/live.

"[27] It was revealed on February 17, 2017 that one of the other reasons that, aside from struggling with Marfan Syndrome, Carlile had left Of Mice & Men was because they did not allow him to write what he wanted on Cold World, the band's next album following Restoring Force.

[32][33] Allegedly, since his time in Costa Rica, some visiting ministers prayed for him and the symptoms of his condition subsided where he could again live an active and healthy lifestyle.

They explained on social media "For legal purposes regarding the Austin Carlile accusations, the story couldn't run as it was told.

"[37] On June 10, 2020, Alternative Press founder Mike Shea posted a statement explaining why the Carlile investigation was never published as expected.