Founded in 2009 by former Sleeping with Sirens and Paddock Park singer Brian Calzini, the band released their only album, Trust in Few, in early 2011 on Tragic Hero.

We Are Defiance quickly gained a loyal fan base and announced to have signed a deal with Tragic Hero Records on May 1, 2010.

On that tour, the band had a van accident and singer Calzini was brought into the hospital and had to undergo surgery.

[10] Fans were allowed to download this song at the band's campaign they started via Twitter called Tweet for a Track.

[13] In May and into June, the band went on the Never Back Down Tour with It Prevails, Life on Repeat, Affiance, and Stand Your Ground.

[21] A month later, the band went on The Walking Revival Tour, with The Great Commission headlining, and Serianna, Convictions, and Your Memorial supporting, from April 16 to May 13.

[25] In December, Calzini stated that the delay for a new album's was due to producer Denney being in studio with his former band A Day to Remember, whose record took longer than intended for production.

On October 14, the band announced their return and their first tour date since their hiatus, which was on February 17, 2017, in Ocala, Florida.

In 2021 the band released the song "Regret" written by vocalist Jason Neil, signifying his return to the group.