It is usually due to destruction of the blood vessels feeding an extremity such as the finger tips.
These chronic wounds might be due to some vascular and pathogenic conditions[4] like Buerger disease or Reynaud's phenomenon.
There have been reported cases of ovarian autoamputation in a newborn[6] and also in a mature ovary of adults.
This is accompanied by inadequate supply of blood to the heart and other body parts (ischemia) leading to the degeneration of the cells, a condition known as atropy.
[3] Chronic or subacute autoamputation is evident in the attachment of the tumor to other cells surrounding it.