The then President of the Republic, Luis Echeverría Álvarez attended on November 29, 1976, to lay the first stone of the university's rectory building.

It is the Supreme Authority of the institution; its resolutions are binding and may only be revoked, modified or added to by the council itself.

The coat of arms was designed in 1977 by architect Donaciano Blanco Flores, according to the historical background of the state of Tlaxcala.

Unidad Académica Multidisciplinaria campus Calpulalpan Multidisciplinary Academic Unit Teacalco campus School of Dentistry Centro de Investigación en Ciencias Administrativas Research Center in Genetics and Environment Center for Interdisciplinary Research on Regional Development' Center for Legal-Political Research and Graduate Studies Tlaxcala Center for Behavioral Biology Faculty of Agrobiology Faculty of Basic Sciences, Engineering and Technology Faculty of Education Sciences.

Faculty of Health Sciences Faculty of Sciences for Human Development School of Law, Political Science and Criminology Facultad de Filosofía y Letras (Faculty of Philosophy and Letters) Faculty of Social Work, Sociology and Psychology Multidisciplinary Academic Unit Biological Sciences Research Center Center for Interdisciplinary Research on Regional Development Center for Research in Administrative Sciences Center for Research in Genetics and Environment Center for Legal-Political Research and Graduate Studies Tlaxcala Center for Behavioral Biology Facultad de Ciencias Básicas Ingeniería y Tecnología Faculty of Educational Sciences Faculty of Sciences for Human Development The university is divided by areas according to its geographical location, both in the city of Tlaxcala de Xicohténcatl and in the rest of the state of Tlaxcala.