The Autostrada A21 or Autostrada dei Vini ("Wines motorway") is an autostrada (Italian for "motorway") 238.3 kilometres (148.1 mi) long in Italy located in the regions of Piedmont, Emilia-Romagna and Lombardy which connects Turin to Brescia, through the Po Valley and the city of Piacenza.

It was inaugurated in 1968.

[1][2] It is nicknamed the "Wines motorway" because it runs through many famous wine areas (Astigiano, Alessandrino, Oltrepò Pavese, Piacentino, reaching Brescia near Franciacorta).

[3] It is a part of the E70 European route.