The rivers of the Wimmera catchment drain into a series of ephemeral lakes that, whilst they do not directly empty into a defined watercourse, form part of the Murray River catchment of the Murray-Darling basin.

The Avon River rises on the northern slopes of the Great Dividing Range, near Beazleys Bridge, west of St Arnaud.

The rivers flows in a highly meandering course generally west by north, joined by one minor tributary, before reaching its mouth to flow into the Richardson River at Banyena; northwest of Marnoo.

[4] In a western Kulin Aboriginal language the river and surrounding country is named Wityellibar, from witji "basket grass" bar "river";[5] and in the Djadjawurrung language, Kurakibiyal, with kurak meaning "sand" and biyal, meaning "red gum".

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