Rising in the Grampians National Park, on the northern slopes of the Great Dividing Range, the Mackenzie River flows generally north by west and drains into the Wimmera River, southwest of Horsham.

The Mackenzie River rises on the northern slopes of the Great Dividing Range, and flows generally west by north, joined by one minor tributary, before reaching its mouth to flow into the Wimmera River at Haven; southwest of Horsham.

The Mackenzie River descends 62 metres (203 ft) over its 57-kilometre (35 mi) course.

In the local Aboriginal language the river is named Bun-nah, meaning "tea-tree scrub"; and in the Jardwadjali language, Bunud, meaning "mallee tree, tea-tree scrub".

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