Supported by Yaknehoz (pseudonym of Yeshaye Nisn Hakoyen Goldberg), while in his early teens Reyzen sent articles to Dos Yudishes folks-blat in Saint Petersburg.

In 1891, they published Reyzen's poem Ven dos lebn is farbitert ("When Life Is Embittered") in their Di yudishe bibliotek (The Yiddish Library).

In addition to writing for the Zionist Der yud, in 1900 Reyzen created the literary anthology Dos tsvantsikste yorhundert (The Twentieth Century) which included work by I. L. Peretz, Hersh Dovid Nomberg, David Pinski, and others.

His Troyerike motivn gevidmet oreme layt (Sad Motifs Dedicated to the Poor) was published (at Sholem Aleichem's recommendation) in Philadelphia’s Shtot tsaytung.

Precisely because he regards being a Jew as a "natural" condition of life, beyond query or challenge, his poems and stories take his culture utterly for granted: they neither explain nor justify"At his death in 1953, Reyzen was eulogized: "There are many Yiddish writers who owe their success to Reisen's encouragement.