She has played a number of roles in both English- and French-language television series and films, such as Dark Matter, Unité 9, and Brick Mansions.
[3] She also did voice acting for Ubisoft's Far Cry Primal and The Dark Pictures Anthology: Man of Medan, which was developed by Supermassive Games and published by Bandai Namco Entertainment, receiving a BAFTA Award for Performer in a Supporting Role nomination.
[6] As a teenager, she suffered from depression, anxiety, and eating disorders,[6] but despite this, she began working toward a modeling career, which proved to be unsuccessful, something she attributed to her athletic build.
[7] By 2010, she had won the heavyweight adult female white belt (novice) category at the International Brazilian Jiu-Jitsu Federation World Championships.
Issa also began venturing into videogame work, starting with voice acting for Ubisoft's Far Cry Primal (2016), which involved learning to speak lines in the developers' reconstructed version of Proto-Indo-European,[7] a hypothesized ancestor of the Indo-European languages.
[7] Rounding out the decade, she played the role of Fliss, a boat captain, in the interactive drama survival horror videogame The Dark Pictures Anthology: Man of Medan (2019), which was developed by Supermassive Games and published by Bandai Namco Entertainment.