Internationally, the song peaked within the top ten of the charts in many countries, including Australia, Denmark and the United Kingdom.

The song has since been covered by Milow, a Belgian singer-songwriter whose version was successful in a number of countries, including Belgium, Spain, Germany, Italy, and the Netherlands.

[7] As revealed within its lyrics, "Ayo Technology" puts a strong emphasis on hot-blooded sexual fantasies, explicit body movements, and wild festivities at nightclubs.

Rob Sheffield from Rolling Stone gave the song a mixed review: "The I-need-love pop tunes are not getting any better, even with Timbaland and Justin Timberlake in the stripper ditty 'Ayo Technology.

'"[8] Pitchfork also gave a mixed review: "The album's only concession to modern pop trends— the Timbaland-produced, Timberlake-hooked "Ayo Technology"—flies off the rails as 50, ripped from his comfort zone, falls behind the gurgling, video-game-blipping beat.

"[9] David Jeffries from AllMusic highlighted and wrote: "At ease is the Timbaland production "Ayo Technology" featuring Justin Timberlake, an obvious single that's "been there, done that" for all parties involved.

An acoustic cover of "Ayo Technology" performed by Belgian singer Milow was released in a number of European countries, topping the charts in the Netherlands,[12] Belgium, Spain, Sweden[13] and Switzerland, and also charting well in countries such as Germany, where the song was certified Platinum for shipping 300,000 copies,[14] as well as in Romania.

Earlier in 2009, Katerine Avgoustakis also made a cover of the song which became her first international single and underwent great success.

"[17]Timbaland's appearance in the music video uses features from the movie Minority Report such as moving computer interfaces with hands.

[18] In the United States, "Ayo Technology" became 50 Cent's second highest debut on the Billboard Hot 100, entering at #22.