"Give It to Me" reached the top position on the Billboard Hot 100, becoming his first and only number one single in the United States as a lead artist (second overall after "Promiscuous").

Following the reported diss, Storch culminated a response song of his own called "Built Like That", where he addresses Timbaland for stealing credit from Danja and claims to be the true producer of "Cry Me a River".

[10] It features a space-age sound that is built of skeletal synths, percussion, bass, low range horns, breathless drums, and digitized keyboards.

[12] David Hyland of WESH Orlando noted the song as "a mellow, slinky club jam that meshes odd, polyrhythmic drumming, a "Twilight Zone" countermelody and digitized keyboard belches with vocals supplied by Furtado and Timberlake.

[14] Furtado begins with rhymes about her change in appearance for her third studio album, with the lines "Love my ass and my abs in the video called 'Promiscuous' / My style is ri-dic-dic-diculous, 'diculous, 'diculous".

[15] Timberlake follows after the second chorus with his verse, where he addresses a rival (allegedly Prince) about his chart success with "SexyBack", present in the lines, "If sexy never left, then why's everybody on my shi-i-i-t?

"[7] Lamb, however, felt it was one-dimensial and repetitive, comparing it to Nelly Furtado's "Say It Right" and Justin Timberlake's "My Love", both produced and co-written by Timbaland.

[7] Andy Kellman of Allmusic writes that "it is immediate enough to connect on the first listen, while Tim also sneaks in enough subtle layers to make it increasingly insidious with each play.

[10] David Hyland of WESH Orlando defines the song as "an example of the outside-the-box approach to hit-making that has earned Tim his reputation" while also praising Furtado and Timberlake for their vocal performances, writing that they sound "seductive" and "convincing as a possible suitor" respectively.

"[16] Norman Mayers of Prefix Magazine declared the song to be one of the album's best tracks, claiming that Timbaland's "fluttering grooves" and Furtado's and Timberlake's "boastful verses" merged perfectly.

[17] PopMatters writer Mike Schiller describes the song as "a combination of every single beat on the Nelly Furtado album (Loose)" while later commenting that, with Timberlake's and Timbaland's vocals, it is an infectious all-star cut.

[18] Steve "Flash" Juon of RapReviews labeled it as a "triumvirate of hip-pop perfection" while Jody Rosen praised it as the catchiest song on the album.

[15][19] Evan McGarvey of Stylus Magazine wrote "The song never comes together though, all of its constituent parts resemble diluted tools from other, more inspired Mosley moments.

[23] The song has, as of July 23, 2010, sold 1,880,000 downloads in the United States, standing as Timbaland's third best selling solo single behind "Apologize" and "The Way I Are".

In Furtado's native Canada, "Give It to Me" debuted at number two on the Canadian Hot 100, where it peaked for one week, on the issue dated June 7, 2007.