It is headquartered in Madison, Georgia and serves the counties of Greene, Hancock, Jasper, Morgan, Putnam, and Walton, of which 32% of the population are members of the library.

[1] Until 2020, the Azalea Regional Library System was named the Uncle Remus Regional Library System for Uncle Remus, a fictional title character and narrator of many African-American folktales, whose stories were compiled by post-Reconstruction Atlanta journalist Joel Chandler Harris in the late 1880s.

The logo for the library system was Br'er Rabbit, who is one of the central figures of Uncle Remus' stories.

[3] Azalea Regional Library System is part of PINES, a statewide public information network which allows for card holders to check out books from any of the 284 associated libraries in Georgia's 143 counties.

[4] It is also a part of Georgia Library Learning Online (GALILEO) which offers databases for research to those with an active subscription.