Azinomycin B is a natural product that contains densely assembled functionalities with potent antitumor activity.

[1] It is isolated from Streptomyces sahachiroi[2] which is reisolated from S. griseofuscus along with its analog azinomycin A.

[3] Azinomycin B can bind within the major groove of DNA and forms covalent interstrand crosslinks (ISCs) with the purine bases.

[4][5][6][7] The DNA alkylation and crosslinking by azinomycin B suggests its potent antitumor activity.

[8] The biosynthesis of azinomycin B includes a type 1 polyketide synthase and several nonribosomal peptide synthetases.