She studied engineering at Autonomous University of Baja California (UABC) where she also started her theatrical career, first appearing as an actress in 1988.
In 2000, Colio was the first Mexican playwright officially invited to an International Residency at the Royal Court Theater in London.
[2][3] Colio has written more than 30 plays, including La boca de lobo, Pequeñas certezas, Usted está aquí, El día más violento, Ventana Amarilla, Cuerdas, Instinto, Humedad, Latir.
Pequenas certezas won the Maria Teresa Leon International Prize, making her the first Mexican writer to win this honour.
[3] Pequenas certezas was produced in Mexico City in 2007 and was also performed in English at the Royal Court Theatre in London in 2006.