B16 melanoma

B16 models were in use to an extent in the 1970s, but it was Dr. Isaiah J. Fidler, a Jerusalem-born, Oklahoma State-trained veterinarian, and University of Pennsylvania-trained biological researcher, now at M.D.

[7][8] In the 1962 edition of the Handbook of Genetically Standardized Jax Mice, the cells were described thus:[9] Gross: soft gray tissue, frequently hemorrhagic.

Pigment greatly decreased in comparison with early transplant generation.Varying surface proteins were shown to play an important part in the locative destiny of the cells on which they are affixed.

[10][11] The presence of high numbers of particular proteins correspond to a cell's affinity for particular organs was selected for in many of the lines perpetuated in labs in the seventies and eighties.

Current research projects focus on the cells’ immunological response to vaccines, microRNA mediated metastatic properties, especially miR-21, a noted aggressor of tumor suppressors and anti-proliferative factors.