[1] The BEN domain is thought to play a critical role in protein-DNA and protein-protein interactions, particularly in gene silencing, transcriptional regulation, and chromatin organization.
It is commonly involved in processes such as development, differentiation, and the maintenance of cellular identity through epigenetic regulation.
This domain is predicted to form an all-alpha fold with four conserved helices.
It has been suggested to mediate protein-DNA and protein-protein interactions during chromatin organization and transcription.
They are generally linked to other globular domains with functions related to transcriptional regulation and chromatin structure, such as BTB, C4DM, and C2H2 fingers.