BR-307 is a Brazilian federal highway in the municipality of São Gabriel da Cachoeira, Amazonas that goes from the main town on the Rio Negro to the Cucuí district some 200 kilometres (120 mi) north at the triple border with Venezuela and Colombia.

[2][3] It passes through the 36,900 hectares (91,000 acres) Morro dos Seis Lagos Biological Reserve, created in 1990.

[4] The 205 kilometres (127 mi) unpaved road is largely impassible due to neglect, destroyed bridges, and heavy rainfall.

BR-307 is still officially listed in government documents as being planned to extend a total of 1695.3 km from Marechal Thaumaturgo, Acre north to the Venezuelan border.

[7] In 2015, the former mayor of São Gabriel da Cachoeira was accused of misappropriating funds that were designated for road maintenance on BR-307.