Much of its characters and setting are inspired from Sumerian and Babylonian mythology, such as The Epic of Gilgamesh and The Tower of Babel.

The series stars Prince Gilgamesh, a gold-armored knight, and the maiden Ki, in their efforts to protect the mythical Blue Crystal Rod and seal away Druaga, a four-armed demon who seeks the rod to enslave the human race.

Dragon Quest co-creator Koichi Nakamura has also cited the series as a key inspiration for him.

International reviews for the series were mixed, with its difficulty and learning curve often criticized, although praise was given for its musical score and historical importance.

In the game's canon, the chronological order is The Quest of Ki, The Tower of Druaga, The Return of Ishtar, and The Blue Crystal Rod.

Also, some side stories were made, including: The player assumes the role of the hero Gilgamesh, whose goal is to rescue the maiden Ki (カイ, Kai) from the demon Druaga.

This game is placed about 100 years after the original Druaga timeline and stars Gilsh, a descendant of Gilgamesh.

It features many Namco cameos, such as Soulcalibur's Nightmare, the sword Soul Edge, Valkyrie, Pac-Man, and even the enemies from Dig Dug.

Gameplay is similar to The Return of Ishtar, only four players may play at the same time; each controlling one of the four available characters: Gil, a young version of Ki, Valkyrie, or an ancient golem named Xeovalga.